Clinical psychoneuroimmunology (PNI) in Seville

Looking at the whole person is not a step away from rigour — here the PNI consultation is a medical one, in the centre of Seville.

You have been tired for months in a way sleep doesn't fix. Your digestion is never quite right. You wake at four in the morning. Something hurts, and it moves around. You have seen a gastroenterologist, maybe an orthopaedist, maybe an endocrinologist, and each one looked at their own patch and found little: your bloods came back within range and nobody has told you that you are ill.

No diagnosis doesn't mean nothing is happening. Sometimes it means that what is happening doesn't fit inside a single specialty. Clinical psychoneuroimmunology looks at how the nervous, immune and endocrine systems talk to each other, and at how sustained stress, sleep, what you eat and how you move shape that conversation. It isn't a parallel medicine: it is a way of reading together what physiology already describes separately.

At Montecarlo that consultation is with a doctor, at Calle Méndez Núñez 12, between Plaza Nueva and Sierpes. The first appointment is a long one, because most of the work is listening to the whole story and putting it in order.

The consultation here is a medical one

If you have searched for a PNI doctor in Seville, you already know why this page exists: psychoneuroimmunology here is offered mostly from physiotherapy and nutrition practices. That is serious work and it often helps, but it is not a medical consultation, and some things can only be done from one.

A doctor can read the reports you already have and tell what was genuinely ruled out and what was left half-answered. A doctor can examine you, request blood work and interpret it, and review your medication and its effects. Above all, a doctor can recognise when what you describe is not a matter of habits but something that needs a specialist or a test — and say so on day one rather than three months in.

When the plan calls for nutrition, physiotherapy, psychology or training, the rest of the clinic's team steps in at the same address and on the same clinical record. You don't have to tell your story from scratch behind every door.

What stress, sleep and digestion have to do with how you feel

The three systems PNI studies don't run in parallel: they regulate each other. Sustained stress alters the hormonal response; that response changes how the immune system behaves; and immune activity in turn affects rest, mood and how you perceive pain. It is a loop, which is why pushing at a single point rarely settles it.

That is where the things a ten-minute appointment has no time for actually matter: how many hours you sleep and how, when and what you eat, how much you move, what you have been carrying and for how long. These are not "lifestyle tips" in the soft sense of the phrase — they are physiological variables acting on the low-grade inflammation that underlies a great deal of persistent symptoms.

That the mechanism exists doesn't mean it explains your case. Part of the work in the consultation is deciding which of it weighs on you and which doesn't, and not accepting a tidy explanation just because it fits.

Almost nobody arrives here with a single symptom

Most people come in with three or four things at once that seem unrelated, and with the feeling of having told half the story at every previous appointment. If your problem is single and clear, the relevant specialty is the sensible route; this consultation is for when you have already been there and an explanation that joins the pieces is still missing.

  • Persistent fatigue that rest doesn't shift, with no obvious cause.
  • Digestion that is never quite right: bloating, irregular bowel habit, symptoms that come and go.
  • Chronic pain, or pain that keeps reappearing in different places.
  • Broken sleep: hard to fall asleep, waking in the early hours, waking unrested.
  • Symptoms that don't fit one specialty and have already been looked at piece by piece.
  • Hormonal transitions, or getting back to normal activity after a bad stretch.

What we ask, what we test for, and what bloods can't prove

The first consultation is mostly questions: when it started and what your life looked like then, how you sleep, what you actually eat in a normal week, how your digestion works, your cycle if you have one, medication and supplements, family history, physical activity, work and rest. Bring the reports and blood tests you already have, even old ones — how a value has moved over time says more than the value on its own.

Depending on what emerges, targeted blood work may be requested: full blood count, iron studies, liver and kidney profile, glucose and insulin, lipid profile, vitamin D, thyroid function or inflammatory markers, among others. We ask for the tests that answer a specific question, not a vast panel just in case.

And it is worth saying what blood work cannot do. There is no test that diagnoses this. A result within range doesn't mean nothing is wrong, and a value out of range is not automatically the cause of how you feel. Numbers support or rule out a hypothesis built by listening to you; on their own, they say very little.

What PNI is not

It is not alternative medicine. What happens here is medicine: clinical history, examination, tests when they add something, and the discipline of not claiming more than is known.

It does not replace your GP or your specialist, and no treatment prescribed by someone else gets changed without going back to whoever prescribed it. Nor does it cure disease: where there is a diagnosis, this work runs alongside its treatment. If something comes up in the consultation that needs another route, urgent or not, you'll be told and referred.

It is not a test that hands you a diagnosis, a list of supplements, or a punishing three-week diet. What you leave with is an explanation of what may be sustaining how you feel, a plan with few things in it at a time, and a date to review it.

Frequently asked questions

Will I be seen by a doctor?

Yes. The clinic's psychoneuroimmunology consultation is a medical appointment: clinical history, examination and, where appropriate, requesting and interpreting tests. Nutrition, physiotherapy or psychology come in afterwards if the plan needs them, working from that same record.

Is this the same as functional or integrative medicine?

They are close relatives and the terms are often used interchangeably. PNI leans more explicitly on the relationship between the nervous, immune and endocrine systems, and uses nutrition, exercise, sleep and stress management as treatment tools. In practice, what matters isn't the label but who runs the consultation and what they do with what they find.

Do I have to stop my treatment or stop seeing my specialist?

No, and please don't do it on your own. Bring your medication and your reports: the plan is built around your treatment, not against it. If something you are taking is worth reviewing, we discuss it with you and raise it with whoever prescribed it.

How long before I notice anything?

It depends on what moves first. Sleep and digestion usually respond earlier; deep fatigue and long-standing pain take longer, because they have been there longer. That is why a review is set for a few weeks in: if nothing has shifted, we change the hypothesis rather than repeat the plan.

Can I be seen in English?

Yes. The clinic works in Spanish and English, and this is a consultation that depends entirely on the conversation, so being seen in your own language matters. Your written plan and test requests can be in English too.

How do I book?

This is a medical appointment and it isn't booked online: call us or leave your details, and reception arranges it with enough time set aside for a long first visit. We are at Calle Méndez Núñez 12, 41001 Seville, between Plaza Nueva and Sierpes.

Shall we talk?

Tell us what is going on and we will tell you who on the team makes sense to start with. No commitment, no rush.